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oai:adakent-rdlopen.rawdatalibrary.net:adakent/100392026-10-21T19:34:44Zopenairecom_adakent_10000col_adakent_10001com_adakent_10007col_adakent_10030

Does α-lipoic acid therapeutically effective against experimentally induced-acute pulpitis in rats?Kermeoğlu, FatmaSayıner, SerkanŞehirli, Ahmet ÖzerSavtekin, GökçeAksoy, UmutIL-1βMMPspulpitisTNF-αα-lipoic acidThe purpose of the study was to investigate the therapeutic effects of α-lipoic acid (ALA) on an induced-acute pulpitis model in rats. Twenty-four Wistar albino rats were randomly divided into three groups: control, induced-acute pulpitis (PULP) and PULP + ALA groups. In the PULP and PULP + ALA groups, the crowns of the maxillary left incisors were removed horizontally. All exposed pulp tissues were treated with 5 µL LPS solution. In the PULP + ALA group, the rats were treated intraperitoneally with a single dose of ALA (100 mg/kg). The rats were sacrificed 24 h after pulp injury, and the trunk blood and pulp samples were collected and then determined using ELISA assay kits. TNF-α, IL-1β, MMP-1 and MMP-2 levels in the serum and pulp tissues were considerably higher in the PULP group than the control group (p < 0.01–0.001). In the PULP + ALA group, TNF-α, IL-1β, MMP-1 and MMP-2 levels in the serum and pulp tissues decreased significantly compared to the PULP group (p < 0.05–0.001). ALA decreases pro-inflammatory mediators and proteolytic enzymes, which might relieve acute inflammation.John Wiley and Sons Inc2023Articlehttps://rdlopen.rawdatalibrary.net/r/adakent/10039https://doi.org/10.1111/aej.126181329-1947enAustralian Endodontic Journalinfo:eu-repo/semantics/closedAccessinfo:eu-repo/semantics/articlehttps://adakent-rdlopen.rawdatalibrary.net/tr/items/adakent/10039