Sürdürülebilir Kalkınma Amaçları

• 10

Alt birimler

• Ağız Diş ve Çene Radyolojisi Anabilim Dalı
• Ağız, Diş ve Çene Cerrahisi Anabilim Dalı
• Endodonti Anabilim Dalı
• Ortodonti Anabilim Dalı
• Pedodonti Anabilim Dalı
• Periodontoloji Anabilim Dalı
• Protetik Diş Tedavisi Anabilim Dalı
• Restoratif Diş Tedavisi Anabilim Dalı

Araştırmacılar(34)

• Adiloglu, Ilgar
• Adson, Onur
• Albayrak, Hasan Can
• Alkhatip, Mohammed
• Alzubaidi, Mohamed Abdulmunem
• Arslaner, Cemile
• Atalar, Habip Ertay
• Aytaç, Duygu
• Bankeroglu, Erol
• Bayar, Celal
• Berberoglu, A.
• Çayır, Işın
• Delican, Esma Fatıma
• Doğan, Esra Sinem Kemer
• Duruel, Onurcem
• Elbahisi, Youssef Hazza Mohamed
• Erçetin, Rahme Özfevzi
• Faki, Süleyman
• Gişi, Hamdi
• Gür, Gözde
• Gür, Gürçağ
• Kalay, Tuğçe
• Karaçöl, Mina Türkmen
• Küçükkaya, Merve
• Özant, Ahmet
• Özen, Tuncer
• Özgen, İhsan Şerif
• Rezaeifard, Fatemeh
• Savtekin, Gökçe
• Shoshaa, Nasser
• Sönmez, Gül
• Şaman, Ebrar Ersarı
• Tuncer, Mustafa Necat
• Yavuz, Esra

• MakaleYalnız künye2026/r/adakent/10068
  Impact of ROI size on fractal dimension values in radiographs using a novel ROI selection method

  Yavuz, Esra; Tunc, Selmi

  Objective: This study aimed to evaluate the effect of various sizes of regions of interest (ROIs) on fractal dimension (FD) in the evaluation of trabecular bone structure in dental radiographic images. Materials and methods: This study included 12 sheep hemimandibles. One set of digital images was obtained from each hemimandible using either periapical radiography, panoramic radiography, or cone-beam computed tomography (CBCT). Fractal analysis (FA) was conducted using ImageJ 1.3 software with the box-counting method on small, medium, and large ROIs obtained from each image, using a novel ROI selection method. Comparisons of FD values obtained from the three different ROI sizes were conducted within each radiographic image using repeated-measures ANOVA. Post hoc pairwise comparisons were performed with Bonferroni correction. Data were analyzed using Jamovi 1.6.23. Statistical significance was accepted as p < 0.05. Results: In periapical radiography, the FD values ​​obtained in small, medium, and large ROI sizes were 1.60 ± 0.02, 1.60 ± 0.01, and 1.65 ± 0.01, respectively (p < 0.001). In panoramic radiography, they were 1.45 ± 0.04, 1.71 ± 0.02, and 1.59 ± 0.01, respectively (p < 0.001), and in CBCT, they were 0.76 ± 0.07, 1.21 ± 0.04, and 1.48 ± 0.04, respectively (p < 0.001). Conclusions: The study demonstrates that FD is affected by the ROI size.

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  İncele
• MakaleAçık Erişim2026/r/adakent/10065
  Evaluation of the effects of A-PRF and oral dexamethasone use on postoperative complications in third molar extraction: a split-mouth randomized-controlled trial

  Elbahisi, Youssef Hazza Mohamed; Keskin Tunç, Serap; Başkan Önal, Aslı; Baydar, Sava

  Background: The aim of this study was to compare the effects of advanced platelet-rich-fibrin (A-PRF) and oral dexamethasone on postoperative complications in patients undergoing impacted mandibular third molar extraction. Methods: This split-mouth, prospective, randomized-controlled study involved bilateral extraction of impacted mandibular third molars. A-PRF was applied to the extraction socket on one side, while postoperative oral dexamethasone was prescribed for the other side. Data were collected on pain, edema, trismus, and analgesic consumption. Intra-group and inter-group comparisons were performed. The Visual Analog Scale (VAS) was used for pain assessment. The patients were given a form to record their postoperative analgesic use. Pain assessments were conducted at postoperative 3, 6, 9, 12, 24 h, and on Days 2, 3, 4, 5, 6, 7, 14, and 30. Maximum interincisal distance was measured for trismus evaluation, while facial measurements between specific points were taken for edema assessment. Trismus and edema measurements were conducted on postoperative Days 2, 7, 14, and 30. Results: This study included 30 patients with bilateral impacted mandibular third molars (total of 60 extractions). The VAS scores were significantly lower on the side treated with oral dexamethasone compared to the A-PRF side at all measurement times (p < 0.01). Considering edema evaluation, measurements were similar between both sides at all time points except on Day 2, when the A-PRF side showed significantly higher values (p = 0.001 and p < 0.01). For trismus evaluation, maximum interincisal distance was significantly greater on the oral dexamethasone side on Days 2 and 7 compared to the A-PRF side (p = 0.001 and p < 0.01). Analgesic consumption was significantly higher in the A-PRF group than in the oral dexamethasone group at all measured time points between 12 h and Day 7 (p < 0.01). Conclusion: Oral dexamethasone appeared to be more effective than A-PRF in reducing postoperative complications. However, no significant difference was observed between the two groups in edema on Days 7, 14, and 30. Although not as effective as oral dexamethasone, A-PRF, being an autologous product with no side effects, can still be considered for reducing complications following impacted tooth extraction. Trial Registration: The study was retrospectively registered at ClinicalTrials.gov with the number of NCT06823934, Registration date 02 June 2025.

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  İncele
• BildiriYalnız künye2024/r/adakent/10051
  Combined Surgical and Orthodontic Treatment for Eruption of the Impacted Premolar Due to a Dentigerous Cyst

  Özant, Ahmet; Ersalıcı, İsmet; Temelci, Ali; Minervini, Giuseppe

  The dentigerous cyst (DC) is a prevalent developmental odontogenic cyst, characterized by an epithelial-lined pathological cavity that is closely related to an unerupted or impacted tooth crown. This cyst is predominantly observed in third molars, maxillary canines, and premolars, and is typically asymptomatic. However, over time bone resorption, minimal bone expansion and tooth displacement may occur. In this case, a 14-year-old female patient was referred to our clinic for a routine radiographic and clinical examination. Radiographic examination revealed an impacted mandibular second premolar tooth and a cystic appearance around the crown of an impacted premolar tooth. CBCT slices showed that the tooth had a close proximity to the mental foramen. After a fine needle aspiration biopsy, the histopathological examination showed that the lesion was an odontogenic cyst which was latterly reported as a dentigerous cyst with the anamnesis and radiographic features. Surgery was planned for the patient under local anesthesia. The visible part of the cyst was removed, the crown of the tooth was exposed and an orthodontic button was placed. The orthodontic force was applied 3 weeks following the surgery to extrude the tooth. After 10 months, the tooth had erupted to the occlusion. Since dentigerous cysts attach to the tooth at the enamel-cementum junction, they can be treated by occlusion of the related tooth. It has been shown that successful treatment can be performed with a conservative approach with surgical and orthodontic planning. In this way, since there is no need for extraction and prevent a possible nerve injury.

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  İncele
• MakaleAçık Erişim2023/r/adakent/10083
  Ameliorative effect of Silk Fibroin against 5-Fluorouracil (5-FU)-induced gastrointestinal damage in rats

  Sexirli, Ahmet Ozer; Aykaç, Asli; Özkayalar, Hanife; Savtekin, Gokge; Sayiner, Serkan

  Objective: 5-Fluorouracil (5-FU), a widely administered anti-cancer drug, causes gastrointestinal damage through various mechanisms. This study aimed to investigate the ameliorative effect of silk fibroin (SF), which has anti-inflammatory and antioxidant properties, against 5 FU-induced gastrointestinal damage. Materials and methods: Wistar albino rats were divided into 3 groups; Control group, 5-FU group (30mg/kg/day on days 0, 2, 4), and 5-FU+SF (30 mg/kg/day 5-FU on days 0, 2, 4 + 600 mg/kg/day SF for 14 days). At the end of the experiment, stomach and intestinal tissue samples were collected and immunohistochemically iNOS, caspase-3, CD4+ and CD8+ were measured. Besides, structural damage was assessed with hematoxylin-eosin and caspase-3 and 9 activities were evaluated using western blot analysis. Results and Discussion: It was determined that iNOS, caspase-3, caspase-9 activities, CD4+ and CD8+ levels and structural damage significantly increased in both stomach and intestinal tissues. Furthermore, elevated markers were regressed almost to control levels in SF administrated group. Conclusion: SF may have an ameliorative effect, thus reducing the gastrointestinal damage caused by 5 FU. More clinical and scientific research should be conducted as the silk fibroin may be a suitable candidate against the adverse effects of chemotherapeuic agents.

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  İncele
• MakaleAçık Erişim2023/r/adakent/10054
  Access Cavity Preparation and Localization of Root Canals Using Guides in 3D-Printed Teeth with Calcified Root Canals: An In Vitro CBCT Study

  Kamburoğlu, Kıvanç; Sönmez, Gül; Koç, Cemre; Yılmaz, Funda; Tunç, Osman; Isayev, Abulfaz

  Pulp canal obliteration (PCO) is a significant complication in endodontics that can occur due to various factors. Cone beam computed tomography (CBCT) is a useful diagnostic tool for identifying root canal anatomy and variations, and guided endodontics is emerging as an alternative treatment solution for teeth with partially or entirely obliterated pulpal canals. However, the accuracy of CBCT-guided 3D-printed guides on different materials and layer thicknesses is not well understood. Therefore, this study aimed to evaluate the accuracy of guides prepared using CBCT images on 3D-printed teeth with stereolithography (SLA) using three different materials and two different layer thicknesses. This study found that 3D-printed guides were accurate and reliable for accessing 3D-manufactured obliterated teeth and reaching the apical area. No significant differences in distance or angle measurements were found when different guide materials were used, suggesting that materials can be selected based on availability and cost. These findings contribute to the knowledge base regarding the effectiveness of 3D printing technology in guided endodontics and can help to identify the most suitable materials and techniques for this application.

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• MakaleAçık Erişim2023/r/adakent/10045
  Cone-beam-computed tomography evaluation of mandibular nutrient canals in patients with periodontal diseases

  Tumer, H.; Orhan, K.; Aksoy, S.; Berberoglu, A.

  Background and Aim: The aim of this study was to evaluate radiographically the prevalence of mandibular nutrient canals (NCs) in patients with/without periodontal bone loss with aging and to correlate the number of NCs with the severity of bone loss using cone-beam-computed tomography (CBCT). Patients and Methods: CBCT examinations of 208 patients were evaluated retrospectively of all patients, 114 had periodontal bone loss, whereas 94 patients were control subjects. Alveolar bone loss investigations were performed according to the Progressive Rate Index. Results: NCs were observed in 55% of the control group and 86% of the periodontitis patients. NCs were more prevalent in the elderly age group with periodontal bone loss. In the study group, the NCs were statistically more frequent than in the control subjects (P > 0.05). Conclusion: Statistical analysis showed a significant difference between the age groups and the prevalence of NCs increased in patients with periodontal alveolar bone loss with aging (P < 0.05).

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  İncele
• MakaleYalnız künye2023/r/adakent/10039
  Does α-lipoic acid therapeutically effective against experimentally induced-acute pulpitis in rats?

  Kermeoğlu, Fatma; Sayıner, Serkan; Şehirli, Ahmet Özer; Savtekin, Gökçe; Aksoy, Umut

  The purpose of the study was to investigate the therapeutic effects of α-lipoic acid (ALA) on an induced-acute pulpitis model in rats. Twenty-four Wistar albino rats were randomly divided into three groups: control, induced-acute pulpitis (PULP) and PULP + ALA groups. In the PULP and PULP + ALA groups, the crowns of the maxillary left incisors were removed horizontally. All exposed pulp tissues were treated with 5 µL LPS solution. In the PULP + ALA group, the rats were treated intraperitoneally with a single dose of ALA (100 mg/kg). The rats were sacrificed 24 h after pulp injury, and the trunk blood and pulp samples were collected and then determined using ELISA assay kits. TNF-α, IL-1β, MMP-1 and MMP-2 levels in the serum and pulp tissues were considerably higher in the PULP group than the control group (p < 0.01–0.001). In the PULP + ALA group, TNF-α, IL-1β, MMP-1 and MMP-2 levels in the serum and pulp tissues decreased significantly compared to the PULP group (p < 0.05–0.001). ALA decreases pro-inflammatory mediators and proteolytic enzymes, which might relieve acute inflammation.

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  İncele
• MakaleAçık Erişim2022/r/adakent/10094
  Detection of Natural and Simulated Periodontal Defects Using Cone-Beam Computed Tomography and Digital Intraoral Radiography

  Misirli, Melis; Aksoy, Secil; Tumer, Hayriye; Bilginaylar, Kani; Karaoglulari, Suzan; Berberoglu, Atilla; Orhan, Kaan; Icen, Murat

  Objectives: In this study, it was aimed to compare the diagnostic value of cone beam computed tomography (CBCT) and digital intraoral periapical imaging methods in the diagnosis of periodontal defects, and the comparison of observers practicing dentistry in the field of periodontology and 3 other observers specialized in various branches was evaluated. Methods: 7 dry mandible and 5 dry maxilla were used in this study. A total of 111 artificial and natural defects (dehiscence, furca, fenestration, vertical defects) on the anterior, premolar and molar region were imaged with digital imaging techniques using different exposure parameters and scanned with CBCT. Results: According to the results of this study, CBCT is a more reliable method in the evaluation of all periodontal defects compared to CCD and PSP. 60 and 70 kVp with 0.01 irradiation time in CCD and 70 kVp 0.25 irradiation time in PSP is not suitable for detecting defects owing to high contrast. In the evaluation of periodontal defects, there was no single observer who had good results, different imaging methods and varying results were obtained in different defects. Conclusion: This study showed that the CBCT method has some diagnostic value for detecting all natural and simulated periodontal defects but it should only be used in cases where clinical evaluation and conventional radiographic imaging do not provide the information necessary for an adequate diagnosis and proper periodontal treatment planning.

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  İncele
• MakaleAçık Erişim2022/r/adakent/10160
  Clinical comparison of intraoral CMOS and PSP detectors in terms of time efficiency, patient comfort, and subjective image quality

  Kamburoğlu, K; Samunahmetoğlu, E; Eratam, N; Sönmez, G; Karahan, S

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  İncele
• MakaleAçık Erişim2021/r/adakent/10162
  In vitro assessment of periapical lesions created in sheep mandibles by using high resolution ultrasonography and cone beam computed tomography

  Kamburoğlu, K; Çakmak, EE; Eratam, N; Sönmez, G; Karahan, S

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