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Araştırmacılar(67)

• Aboud, Farida
• Adiloglu, Ilgar
• Adson, Onur
• Ahmadi, Newsha
• Albayrak, Hasan Can
• Alkhatip, Mohammed
• Alpuğan, Zeynep
• Altınkan, Onur
• Alzubaidi, Mohamed Abdulmunem
• Aranoğlu, Cansu İste
• Arslaner, Cemile
• Atalar, Habip Ertay
• Aytaç, Duygu
• Bankeroglu, Erol
• Bashiri, Vali
• Bayar, Celal
• Bayatlı, Nur
• Berberoglu, A.
• Cengiz, Serkan
• Delican, Esma Fatıma
• Demiryürek, Esra
• Doğan, Esra Sinem Kemer
• Duruel, Onurcem
• Elbahisi, Youssef Hazza Mohamed
• Erçetin, Rahme Özfevzi
• Erten, Çağatay
• Eski, Mehmet
• Eskimuhtaroğlu, Cenan
• Faki, Süleyman
• Fırat, Hicran Bayraktaroğlu
• Fırıncıoğulları, Cansu
• Gişi, Hamdi
• Gümüş, Bedia Ayşegül Tansen
• Gün, Zübeyit
• Gür, Gözde
• Gür, Gürçağ
• Hamurtekin, Yeşim
• Hussain, Adedoyin Ahmed
• Jermsittiparsert, Kittisak
• Kalay, Tuğçe
• Karaçöl, Mina Türkmen
• Karasu, Sinem
• Karslı, Gözdecan
• Kaya, Emin Kaan
• Keçecioğlu, Burak
• Kiziroglu, Serap Keskin
• Koçak, Asrın Akın
• Korsheed, Amena Savgan
• Küçükkaya, Merve
• Muluk, Gizem
• Rezaeifard, Fatemeh
• Sarlak, Deniz
• Savtekin, Gökçe
• Shoshaa, Nasser
• Sönmez, Gül
• Tuncer, Mustafa Necat
• Ulukök, Mehtap Köse
• Wongmahesak, Kittisak
• Yavuz, Esra
• Zarbakhsh, Payam

• MakaleYalnız künye2026/r/adakent/10068
  Impact of ROI size on fractal dimension values in radiographs using a novel ROI selection method

  Yavuz, Esra; Tunc, Selmi

  Objective: This study aimed to evaluate the effect of various sizes of regions of interest (ROIs) on fractal dimension (FD) in the evaluation of trabecular bone structure in dental radiographic images. Materials and methods: This study included 12 sheep hemimandibles. One set of digital images was obtained from each hemimandible using either periapical radiography, panoramic radiography, or cone-beam computed tomography (CBCT). Fractal analysis (FA) was conducted using ImageJ 1.3 software with the box-counting method on small, medium, and large ROIs obtained from each image, using a novel ROI selection method. Comparisons of FD values obtained from the three different ROI sizes were conducted within each radiographic image using repeated-measures ANOVA. Post hoc pairwise comparisons were performed with Bonferroni correction. Data were analyzed using Jamovi 1.6.23. Statistical significance was accepted as p < 0.05. Results: In periapical radiography, the FD values ​​obtained in small, medium, and large ROI sizes were 1.60 ± 0.02, 1.60 ± 0.01, and 1.65 ± 0.01, respectively (p < 0.001). In panoramic radiography, they were 1.45 ± 0.04, 1.71 ± 0.02, and 1.59 ± 0.01, respectively (p < 0.001), and in CBCT, they were 0.76 ± 0.07, 1.21 ± 0.04, and 1.48 ± 0.04, respectively (p < 0.001). Conclusions: The study demonstrates that FD is affected by the ROI size.

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• MakaleAçık Erişim2026/r/adakent/10065
  Evaluation of the effects of A-PRF and oral dexamethasone use on postoperative complications in third molar extraction: a split-mouth randomized-controlled trial

  Elbahisi, Youssef Hazza Mohamed; Keskin Tunç, Serap; Başkan Önal, Aslı; Baydar, Sava

  Background: The aim of this study was to compare the effects of advanced platelet-rich-fibrin (A-PRF) and oral dexamethasone on postoperative complications in patients undergoing impacted mandibular third molar extraction. Methods: This split-mouth, prospective, randomized-controlled study involved bilateral extraction of impacted mandibular third molars. A-PRF was applied to the extraction socket on one side, while postoperative oral dexamethasone was prescribed for the other side. Data were collected on pain, edema, trismus, and analgesic consumption. Intra-group and inter-group comparisons were performed. The Visual Analog Scale (VAS) was used for pain assessment. The patients were given a form to record their postoperative analgesic use. Pain assessments were conducted at postoperative 3, 6, 9, 12, 24 h, and on Days 2, 3, 4, 5, 6, 7, 14, and 30. Maximum interincisal distance was measured for trismus evaluation, while facial measurements between specific points were taken for edema assessment. Trismus and edema measurements were conducted on postoperative Days 2, 7, 14, and 30. Results: This study included 30 patients with bilateral impacted mandibular third molars (total of 60 extractions). The VAS scores were significantly lower on the side treated with oral dexamethasone compared to the A-PRF side at all measurement times (p < 0.01). Considering edema evaluation, measurements were similar between both sides at all time points except on Day 2, when the A-PRF side showed significantly higher values (p = 0.001 and p < 0.01). For trismus evaluation, maximum interincisal distance was significantly greater on the oral dexamethasone side on Days 2 and 7 compared to the A-PRF side (p = 0.001 and p < 0.01). Analgesic consumption was significantly higher in the A-PRF group than in the oral dexamethasone group at all measured time points between 12 h and Day 7 (p < 0.01). Conclusion: Oral dexamethasone appeared to be more effective than A-PRF in reducing postoperative complications. However, no significant difference was observed between the two groups in edema on Days 7, 14, and 30. Although not as effective as oral dexamethasone, A-PRF, being an autologous product with no side effects, can still be considered for reducing complications following impacted tooth extraction. Trial Registration: The study was retrospectively registered at ClinicalTrials.gov with the number of NCT06823934, Registration date 02 June 2025.

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• BildiriAçık Erişim2026/r/adakent/10060
  Explainable Attention-Guided Swin Transformer Networks for Brain Tumor Segmentation from 3D MRI

  Ranjbarzadeh, Ramin; Keles, Ayse; Anari, Shokofeh; Zarbakhsh, Payam; Bendechache, Malika

  This research presents a two-stage cascaded 3D segmentation approach designed for accurate brain tumor delineation in multimodal MRI data. The design incorporates a Swin Transformer backbone alongside Atrous Spatial Pyramid Pooling (ASPP) and Squeeze-and-Excitation (SE) blocks during the coarse segmentation phase to extract comprehensive, multi-scale contextual data. The second stage enhances the preliminary output with a class-wise attention decoder, which highlights tumor subregions—specifically, edema, necrotic core, and enhancing tumor—by masking the original input with the coarse predictions. The model employs a weighted Tversky loss to address the substantial class imbalance present in tumor segmentation tasks. Extensive experiments were executed on the BraTS 2020 dataset, incorporating preprocessing processes such as volume cropping and scaling to 128 × 128 × 128, with evaluation completed across training, validation, and test sets divided in a 70%–15%–15% ratio. The model exhibited exceptional accuracy in identifying tumor regions, with a Dice score of 0.99 for healthy tissue and above 0.5 for tumor subregions. The investigation of ROC curves and confusion matrices further substantiated the reliability of the forecasts. To improve model transparency, layer-wise Grad-CAM heatmaps were produced, illustrating the transition of attention from general background in first levels to concentrated tumor localization in subsequent layers. The proposed method attains competitive segmentation performance while providing a more interpretable and therapeutically pertinent answer. The results underscore the efficacy of integrating coarse-to-fine cascaded architectures with transformer-based encoders and attention-driven refinement for brain tumor segmentation.

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• MakaleAçık Erişim2026/r/adakent/10057
  Explainable deep learning framework for brain tumor segmentation using vision transformer and conditional random fields

  Safarpour, Homayoun; Sadeghi, Soroush; Zarbakhsh, Payam; Kamsari, Mohammadreza; Kia, Marjan; Ranjbarzadeh, Ramin

  Brain tumor segmentation is critical for accurate identification and treatment planning. However, delineating intricate tumor areas like Edema, Tumor Core, and Enhancing Tumor remains challenging owing to diversity in dimensions, morphology, and delineation. This introduces a novel deep learning model integrating a pretrained Vision Transformer (ViT) for global context representation, Atrous Spatial Pyramid Pooling (ASPP) in both encoder and merging stages, and ReLU6. Additionally, attention mechanisms and Conditional Random Fields (CRF) were incorporated for refining feature emphasis and segmentation boundaries. The model was trained and tested on the BraTS 2020 dataset and compared with state-of-the-art methods. The suggested model obtained the highest Dice coefficients across all tumor regions, with improvements of up to 4% over nnU-Net and SwinBTS in the Enhancing Tumor and Edema region. Grad-CAM heatmaps illustrated the model’s proficiency in precisely identifying tumor areas, hence enhancing the interpretability of predictions. The incorporation of multi-scale feature extraction, attention mechanism, and global context representation markedly improved segmentation accuracy and interpretability. The findings underscore the proposed model’s capacity to enhance clinical processes and establish a standard for brain tumor segmentation tasks. Future endeavors involve testing on varied datasets and investigating lightweight structures for real-time applications.

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• Kitap BölümüYalnız künye2025/r/adakent/10071
  Balancing Innovation and Access: The Role of Intellectual Property in Healthcare

  Wongmahesak, Kittisak

  The pace of development in medical technology and pharmaceuticals is continuing to increase, making the impact that intellectual property (IP) has on healthcare even more important. The part of the chapter starts with types of IP patents, trademarks, copyrights, and trade secrets in healthcare research and development (R&D). On the one hand, it points out that strong IP protections spur innovation by enabling firms to capture a return on R&D spending, hence creating new issues about high drug prices and limited access among disadvantaged populations. The review also includes international trade agreements like the Trade-Related Aspects of Intellectual Property Rights (TRIPS) Agreement and Doha Declaration, which work for a strike of balance between IP rights and public health needs. The chapter advocates for the use of flexibilities within these frameworks such as compulsory licensing to improve access to life-saving treatments in public health emergencies. It concludes with a comparison of the ways in which IP is addressed in healthcare across nations illustrating that countries like India have found solutions where they prioritize public health and yet do not compromise on innovation. The chapter concludes with some ethical reflections on who should bear the cost in terms of lost profit when essential treatments are not accessible to those (M) CBs: patients, insurers, or pharm industries.

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• MakaleYalnız künye2024/r/adakent/10075
  Nexus between good governance and financial sustainability: evidence from microfinance sector of India

  Maeenuddin, M.; Hamid, Shaari Abdul; Nassir, Annuar Md; Fahlevi, Mochammad; Aljuaid, Mohammed; Jermsittiparsert, Kittisak

  Purpose: Microfinance emerged as an essential catalyst for socio-economic development and financial inclusion to reduce poverty. Microfinance institutions cannot meet their primary objective of poverty reduction if they are not sustainable financially. With the theoretical support of profit incentive theory, this paper aims to investigate the impact of organizational structure (OS), growth outreach (average loan per borrower [ALPB] and number of active borrowers), women empowerment (percentage of women borrowers [PWB]), liquidity, leverage and cost efficiency (cost per borrower) on the financial sustainability of microfinance providers (MFPs) in India and explore the possible moderating effect of the national governance indicators (NGIs). Design/methodology/approach: A financial sustainability index has been developed by using principal components analysis, including both conventional measures (return of assets and return on equity) and efficiency measures (operational self-sufficiency and financial self-sufficiency). Due to the existence of endogeneity and heteroskedasticity, this study uses two-step system generalized method of moments estimates to examine the relationships for a period of 2006 to 2018. Findings: The finding reveals that there is a strong significant relationship between financial sustainability and its influential factors. Organizatioanl Structure, loan size, women borrowers, Gross Domestic Products and inflation enhance the financial sustainability of India’s microfinance sector. However, a number of borrowers, liquidity, leverage and operating costs negatively affect the financial sustainability of MFPs of India. The estimates demonstrate that NGIs significantly moderate the association between financial sustainability and its influential factors. The NGIs negatively affect the positive impact of Organizatioanl Structure on financial sustainability. National governance increases the positive effect of loan size (ALPB) and reduces the negative effect of a number of borrowers and leverage on the financial sustainability of MFPs of India. However, NGIs negatively affect the positive relationship between Percentage of Women Borrowers and Financial sustainability of Microfinance Providers of India. Originality/value: To the best of the authors’ knowledge, this study is the first of its kind that incorporates all of the six dimensions of the National Governance Indicators (NGIs) and uses as a moderator. Secondly, a financial sustainability index has been developed for measuring the financial sustainability of Microfinance Providers (MFPs).

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• MakaleAçık Erişim2024/r/adakent/10073
  Measuring the Financial Sustainability and its Influential Factors in Microfinance Sector of Pakistan

  Maeenuddin; Hamid, Shaari Abd; Nassir, Annuar MD; Fahlevi, Mochammad; Aljuaid, Mohammed; Jermsittiparsert, Kittisak

  Financial sustainability is one of the major issues in the development process, particularly in developing countries. Microfinance started with two basic objectives of poverty reduction and women empowerment. However, unsustainable microfinance providers cannot assist the poor for a longer period of time, due to uncertainty about their existence. This study investigates that how financial sustainability of Pakistan’s microfinance sector is affected by various factors. A new financial sustainability index has been developed to measure the financial sustainability. Generalized Method of Moments (GMM) approach is employed to analyze the panel data from 34 Pakistani MFPs, yielding 344 MFI-years of observations from 2006 to 2018. The findings reveal that increase in loan size, female borrowers, liquidity, and leverage significantly enhances the financial viability of Microfinance Providers in Pakistan. However, the total borrowers and the operating cost per borrower negatively affect the financial sustainability of MFPs in Pakistan. MFIs needs to be financially independent, with less or no support from government or donor agencies. Financially sustainable MFPs contributes in the achievement of the 8 out of 17 Sustainable Development of Goals (2030 SDGs) of the United Nation. The data for 2018 onwards is seriously affected by COVID-19, which cannot be included in the current data set. Hence, researchers in future analyze the data from the pre-COVID-19 and post-COVID-19 periods to compare the analysis and examine the pandemic’s impact.

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• BildiriYalnız künye2024/r/adakent/10051
  Combined Surgical and Orthodontic Treatment for Eruption of the Impacted Premolar Due to a Dentigerous Cyst

  Özant, Ahmet; Ersalıcı, İsmet; Temelci, Ali; Minervini, Giuseppe

  The dentigerous cyst (DC) is a prevalent developmental odontogenic cyst, characterized by an epithelial-lined pathological cavity that is closely related to an unerupted or impacted tooth crown. This cyst is predominantly observed in third molars, maxillary canines, and premolars, and is typically asymptomatic. However, over time bone resorption, minimal bone expansion and tooth displacement may occur. In this case, a 14-year-old female patient was referred to our clinic for a routine radiographic and clinical examination. Radiographic examination revealed an impacted mandibular second premolar tooth and a cystic appearance around the crown of an impacted premolar tooth. CBCT slices showed that the tooth had a close proximity to the mental foramen. After a fine needle aspiration biopsy, the histopathological examination showed that the lesion was an odontogenic cyst which was latterly reported as a dentigerous cyst with the anamnesis and radiographic features. Surgery was planned for the patient under local anesthesia. The visible part of the cyst was removed, the crown of the tooth was exposed and an orthodontic button was placed. The orthodontic force was applied 3 weeks following the surgery to extrude the tooth. After 10 months, the tooth had erupted to the occlusion. Since dentigerous cysts attach to the tooth at the enamel-cementum junction, they can be treated by occlusion of the related tooth. It has been shown that successful treatment can be performed with a conservative approach with surgical and orthodontic planning. In this way, since there is no need for extraction and prevent a possible nerve injury.

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• MakaleAçık Erişim2023/r/adakent/10083
  Ameliorative effect of Silk Fibroin against 5-Fluorouracil (5-FU)-induced gastrointestinal damage in rats

  Sexirli, Ahmet Ozer; Aykaç, Asli; Özkayalar, Hanife; Savtekin, Gokge; Sayiner, Serkan

  Objective: 5-Fluorouracil (5-FU), a widely administered anti-cancer drug, causes gastrointestinal damage through various mechanisms. This study aimed to investigate the ameliorative effect of silk fibroin (SF), which has anti-inflammatory and antioxidant properties, against 5 FU-induced gastrointestinal damage. Materials and methods: Wistar albino rats were divided into 3 groups; Control group, 5-FU group (30mg/kg/day on days 0, 2, 4), and 5-FU+SF (30 mg/kg/day 5-FU on days 0, 2, 4 + 600 mg/kg/day SF for 14 days). At the end of the experiment, stomach and intestinal tissue samples were collected and immunohistochemically iNOS, caspase-3, CD4+ and CD8+ were measured. Besides, structural damage was assessed with hematoxylin-eosin and caspase-3 and 9 activities were evaluated using western blot analysis. Results and Discussion: It was determined that iNOS, caspase-3, caspase-9 activities, CD4+ and CD8+ levels and structural damage significantly increased in both stomach and intestinal tissues. Furthermore, elevated markers were regressed almost to control levels in SF administrated group. Conclusion: SF may have an ameliorative effect, thus reducing the gastrointestinal damage caused by 5 FU. More clinical and scientific research should be conducted as the silk fibroin may be a suitable candidate against the adverse effects of chemotherapeuic agents.

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• MakaleAçık Erişim2023/r/adakent/10107
  Adoption of the Green Economy through Branchless Rural Credit Banks during the COVID-19 Pandemic in Indonesia

  Marhaeni, A. A. I. N.; Jermsittiparsert, Kittisak; Sudarmo, Lucia Rita; Indrawati, Lucia Rita; Prasetyo, Andjar; Fuada, Noviati; Rachmadhani, Arnis; Raharjo, Tri Weda; Wahyudianto, Heri; Harwijayanti, Bekti Putri

  A green economy has an impact on improving welfare, but it takes continuous efforts to achieve it from various fields. Contribution in the context of banking on a small scale is one of the initiatives that can show participation in achieving a green economy. This study aims to explore people's behavior in financial transactions and analyze the practice of rural credit banks in encouraging the achievement of a green economy through the National Financial Inclusive Strategy (NFIS) program despite the COVID-19 pandemic. This study used quantitative approaches; observations were conducted at a certain time by collecting data taken directly as a complement to this study, as well as taking questionnaire data involving 363 samples and analyzing them using the structural equation model (SEM). The result is that green economic support is found in using paper for fewer savings transactions compared to branchless banking with conventional savings transactions. The high number of residents exposed to COVID-19 does not affect branchless banking. In addition, the use of branchless banking can show the penetration of financial literacy in the community. The results of the path analysis explain that perceived ease of use (7.468) and perceived usefulness (2.152) have an influence on attitude; intention is greatly influenced by attitude (15.357); and actual usage is influenced by intention (11.682). This research has specific implications for the Magelang City Rural Bank (MCRB), which needs to conduct market research to find out the potential of branchless banking that is specifically needed by the people of Magelang. Branchless banking innovation needs to be strengthened by presenting easy-to-understand and easy-to-use applications to improve the attitude of the Magelang people in adopting branchless banking applications and using them sustainably.

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